"Welcome to the Black Parade" was released as a single on September 11, 2006. On September 26, 2006, the music video for "Welcome to the Black Parade" was released in the UK, and on September 27 in the US.^[13] The single became the band's first number one on the UK Singles Chart in October 2006. The Black Parade was released on October 23, 2006 in the United Kingdom and on October 24, 2006 in the United States.

The Black Parade World Tour commenced on February 22, 2007, with the eventuating 133 shows featuring Rise Against, Thursday and Muse as support acts.^[17] Reggie and the Full Effect frontman James Dewees played keyboards and synthesizer on the tour. In April 2007, it was announced that Mikey Way would temporarily leave the tour to spend time with his new wife, Alicia Simmons-Way. Way's temporary replacement was Matt Cortez, a friend of the band.^[18] During the third leg of the tour, as a support act for Muse, members of My Chemical Romance and their crew, along with members of Muse's crew, suffered food poisoning, and consequently had to cancel six shows.^[19] The band later featured on Linkin Park's Projekt Revolution tour in 2007,^[20] along with Placebo, Mindless Self Indulgence, Saosin, Taking Back Sunday and HIM.